The amyloid code

For more than a decade, many scientists have believed that the amyloid-beta protein triggers a series of steps--dubbed the amyloid cascade--that leads to the memory loss and dementia in those afflicted with Alzheimer disease. But some researchers say that those who believe the amyloid cascade hypoth...

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Bibliographic Details
Published inNature medicine Vol. 12; no. 7; pp. 747 - 751
Main Author Mandavilli, Apoorva
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.07.2006
Subjects
Alzheimer Disease - drug therapy
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid - genetics
Amyloid beta-Peptides - genetics
Brain
Brain - pathology
Brain - physiopathology
Dementia disorders
Humans
Medical research
Memory Disorders - drug therapy
Memory Disorders - genetics
Models, Neurological
Neurons - pathology
Neurons - physiology
Proteins
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Summary:For more than a decade, many scientists have believed that the amyloid-beta protein triggers a series of steps--dubbed the amyloid cascade--that leads to the memory loss and dementia in those afflicted with Alzheimer disease. But some researchers say that those who believe the amyloid cascade hypothesis have unwisely pushed it, perhaps to the detriment of the whole field.
Bibliography:SourceType-Other Sources-1
ObjectType-News-1
content type line 66
ISSN:1078-8956
1546-170X
DOI:10.1038/nm0706-747