Diagnostic performance of diffusion-weighted magnetic resonance imaging in bladder cancer: potential utility of apparent diffusion coefficient values as a biomarker to predict clinical aggressiveness

• Published in: European radiology Vol. 21; no. 10; pp. 2178 - 2186
• Main Authors: Kobayashi, Shuichiro, Koga, Fumitaka, Yoshida, Soichiro, Masuda, Hitoshi, Ishii, Chikako, Tanaka, Hiroshi, Komai, Yoshinobu, Yokoyama, Minato, Saito, Kazutaka, Fujii, Yasuhisa, Kawakami, Satoru, Kihara, Kazunori
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.10.2011; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers - metabolism; Bladder cancer; Diagnostic Radiology; Diffusion; Diffusion Magnetic Resonance Imaging - methods; Female; Humans; Image Processing, Computer-Assisted; Imaging; Internal Medicine; Interventional Radiology; Magnetic REsonance; Magnetic Resonance Imaging - methods; Male; Medical Oncology - methods; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging - methods; Neuroradiology; Phenotype; Radiology; Reproducibility of Results; Sensitivity and Specificity; Ultrasound; Urinary Bladder Neoplasms - diagnosis; Urinary Bladder Neoplasms - pathology; Urinary bladder neoplasms; Diagnosis; Neoplasm staging; Biological markers; Diffusion magnetic resonance imaging
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-011-2174-7

Objectives The diagnostic performance of diffusion-weighted magnetic resonance imaging (DW-MRI) in bladder cancer and the potential role of apparent diffusion coefficient (ADC) values in predicting pathological bladder cancer phenotypes associated with clinical aggressiveness were investigated. Methods One hundred and four bladder cancer patients underwent DW-MRI and T2-weighted magnetic resonance imaging (T2W-MRI) before transurethral resection. The image sets were reviewed by two independent radiologists. ADC values were measured in 121 eligible tumours. Results In detecting patients with bladder cancer, DW-MRI exhibited high sensitivity equivalent to that of T2W-MRI (>90%). Interobserver agreement was excellent for DW-MRI (κ score, 0.88) though moderate for T2W-MRI (0.67). ADC values were significantly lower in high-grade (vs. low-grade, P  < 0.0001) and high-stage (T2 vs. T1 vs. Ta, P  < 0.0001) tumours. At a cut-off ADC value determined by partition analysis, clinically aggressive phenotypes including muscle-invasive bladder cancer (MIBC) and high-grade T1 disease were differentiated from less aggressive phenotypes with a sensitivity of 88%, a specificity of 85% and an accuracy of 87%. Conclusion DW-MRI exhibits high diagnostic performance in bladder cancer with excellent objectivity. The ADC value could potentially serve as a biomarker to predict clinical aggressiveness in bladder cancer.