Occlusive Fungal Tracheitis in 4 Captive Bottlenose Dolphins (Tursiops truncatus)

Respiratory disease is common in dolphins, primarily affecting pulmonary parenchyma and sparing large airways. Over a 10-year period, 4 captive adult bottlenose dolphins succumbed to chronic, progressive respiratory disease with atypical recurrent upper respiratory signs. All dolphins had severe, se...

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Published inVeterinary pathology Vol. 50; no. 1; pp. 172 - 176
Main Authors Delaney, M. A., Terio, K. A., Colegrove, K. M., Briggs, M. B., Kinsel, M. J.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2013
Subjects
Animals
Animals, Zoo
Aspergillosis - microbiology
Aspergillosis - pathology
Aspergillosis - veterinary
Aspergillus - classification
Aspergillus - genetics
Aspergillus - isolation & purification
Aspergillus fumigatus
Bottle-Nosed Dolphin
DNA, Fungal - genetics
Female
Hyphae
Immunohistochemistry - veterinary
Lung - microbiology
Lung - pathology
Male
Recurrence
Sequence Analysis, DNA - veterinary
Trachea - microbiology
Trachea - pathology
Tracheitis - microbiology
Tracheitis - pathology
Tracheitis - veterinary
Tursiops truncatus
Zygomycetes
Aspergillus
dolphin
fungi
tracheitis
immunohistochemistry
zygomycete
Tursiops truncatus
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Summary:Respiratory disease is common in dolphins, primarily affecting pulmonary parenchyma and sparing large airways. Over a 10-year period, 4 captive adult bottlenose dolphins succumbed to chronic, progressive respiratory disease with atypical recurrent upper respiratory signs. All dolphins had severe, segmental to circumferential fibrosing tracheitis that decreased luminal diameter. Histologically, tracheal cartilage, submucosa, and mucosa were distorted and replaced by extensive fibrosis and pyogranulomatous inflammation centered on fungal hyphae. In 3 of 4 cases, hyphae were morphologically compatible with Aspergillus spp and confirmed by culture in 2 cases. Amplification of fungal DNA from tracheal tissue was successful in one case, and sequences had approximately 98% homology to Aspergillus fumigatus. The remaining case had fungi compatible with zygomycetes; however, culture and polymerase chain reaction were unsuccessful. Lesions were evaluated immunohistochemically using antibodies specific to Aspergillus spp. Aspergillus-like hyphae labeled positively, while presumed zygomycetes did not. These cases represent a novel manifestation of respiratory mycoses in bottlenose dolphins.
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ISSN:0300-9858
1544-2217
DOI:10.1177/0300985812446153