Cimetidine and ranitidine do not affect enflurane metabolism in surgical patients

Hepatic cytochrome-P-450-linked microsomal metabolism is inhibited by cimetidine, and to a lesser extent by ranitidine. Such an inhibition might protect against the metabolite-related toxicity of inhalation anesthetics. However, in comparison with the values measured in a control group, neither cime...

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Bibliographic Details
Published inActa anaesthesiologica Scandinavica Vol. 33; no. 2; p. 129
Main Authors Oikkonen, M, Rosenberg, P H, Saarnivaara, L
Format Journal Article
LanguageEnglish
Published England 01.02.1989
Subjects
Aged
Cimetidine - therapeutic use
Clinical Trials as Topic
Enflurane - adverse effects
Enflurane - metabolism
Female
Fluorides - blood
Fluorides - metabolism
Fluorides - urine
Gastric Juice - metabolism
Humans
Male
Middle Aged
Random Allocation
Ranitidine - therapeutic use
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Summary:Hepatic cytochrome-P-450-linked microsomal metabolism is inhibited by cimetidine, and to a lesser extent by ranitidine. Such an inhibition might protect against the metabolite-related toxicity of inhalation anesthetics. However, in comparison with the values measured in a control group, neither cimetidine (600 mg p.o. + 200 mg i.m.) nor ranitidine (150 mg p.o. + 50 mg i.m.), both administered 11-12 h before anesthesia, inhibited enflurane metabolism as assessed by the increase in plasma inorganic fluoride concentration and urinary fluoride excretion in 21 ASA I patients anesthetized with enflurane (end-tidal concentration 0.5 +/- 0.05% for 2-6 h). The inorganic fluoride concentration in the gastric juice remained low in all groups.
ISSN:0001-5172
DOI:10.1111/j.1399-6576.1989.tb02874.x