Early evoked brain activity underlies auditory and audiovisual speech recognition deficits in schizophrenia

• Published in: NeuroImage clinical Vol. 33; p. 102909
• Main Authors: Senkowski, Daniel, Moran, James K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2022; Elsevier
• Subjects: Acoustic Stimulation; Attention; Audiovisual N1 suppression; Brain; Cognition; Crossmodal; Electroencephalography; Evoked Potentials, Auditory; Humans; Patients; Regular; Schizophrenia - complications; Speech; Speech Perception - physiology; Visual Perception - physiology; Cognition; Audiovisual N1 suppression; Patients; Attention; Crossmodal
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2021.102909

•Reduced N1 amplitudes reflect speech processing deficits in schizophrenia (SZ).•Crossmodal N1 amplitude suppression in audiovisual speech is preserved in SZ.•N1 amplitudes correlate with speech recognition performance in controls but not in SZ. People with Schizophrenia (SZ) show deficits in auditory and audiovisual speech recognition. It is possible that these deficits are related to aberrant early sensory processing, combined with an impaired ability to utilize visual cues to improve speech recognition. In this electroencephalography study we tested this by having SZ and healthy controls (HC) identify different unisensory auditory and bisensory audiovisual syllables at different auditory noise levels. SZ (N = 24) and HC (N = 21) identified one of three different syllables (/da/, /ga/, /ta/) at three different noise levels (no, low, high). Half the trials were unisensory auditory and the other half provided additional visual input of moving lips. Task-evoked mediofrontal N1 and P2 brain potentials triggered to the onset of the auditory syllables were derived and related to behavioral performance. In comparison to HC, SZ showed speech recognition deficits for unisensory and bisensory stimuli. These deficits were primarily found in the no noise condition. Paralleling these observations, reduced N1 amplitudes to unisensory and bisensory stimuli in SZ were found in the no noise condition. In HC the N1 amplitudes were positively related to the speech recognition performance, whereas no such relationships were found in SZ. Moreover, no group differences in multisensory speech recognition benefits and N1 suppression effects for bisensory stimuli were observed. Our study suggests that reduced N1 amplitudes reflect early auditory and audiovisual speech processing deficits in SZ. The findings that the amplitude effects were confined to salient speech stimuli and the attenuated relationship with behavioral performance in patients compared to HC, indicates a diminished decoding of the auditory speech signals in SZs. Our study also revealed relatively intact multisensory benefits in SZs, which implies that the observed auditory and audiovisual speech recognition deficits were primarily related to aberrant processing of the auditory syllables.