Ceroid pigment deposition in circulating blood monocytes and T lymphocytes in Hermansky-Pudlak syndrome: an ultrastructural study

An electron microscopic study of peripheral leukocytes obtained from a 39 year old woman with Hermansky-Pudlak syndrome was performed. Ceroid pigment granules were found within the lysosomes in 3.5% of monocytes and 5.4% of lymphocytes. Infrequently, pigment granules were also found in the parallel...

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Published inPathology international Vol. 45; no. 11; p. 866
Main Authors Sakuma, T, Monma, N, Satodate, R, Satoh, T, Takeda, R, Kuriya, S
Format Journal Article
LanguageEnglish
Published Australia 01.11.1995
Subjects
Adult
Albinism, Oculocutaneous - immunology
Albinism, Oculocutaneous - pathology
Ceroid - blood
Female
Humans
Microscopy, Immunoelectron
Monocytes - chemistry
Monocytes - ultrastructure
T-Lymphocytes - chemistry
T-Lymphocytes - ultrastructure
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Summary:An electron microscopic study of peripheral leukocytes obtained from a 39 year old woman with Hermansky-Pudlak syndrome was performed. Ceroid pigment granules were found within the lysosomes in 3.5% of monocytes and 5.4% of lymphocytes. Infrequently, pigment granules were also found in the parallel tubular arrays of lymphocytes. The lymphocytes containing ceroid pigment granules were confirmed to be T cells by immunoelectron microscopy. It was speculated that intralysosomal accumulation of ceroid pigment granules in Hermansky-Pudlak syndrome may be due to lysosomal dysfunction.
ISSN:1320-5463
DOI:10.1111/j.1440-1827.1995.tb03407.x