Total Synthesis of Enzyme Inhibitor Spirastrellolide A--Stereochemical Confirmation

Problem solved: Spirastrellolide A methyl ester (see picture) is a potent phosphatase 2A inhibitor and has been the subject of considerable synthetic interest since its isolation in 2003. Paterson and co‐workers have now succeeded in the total synthesis of this compound by using a flexible modular s...

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Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 47; no. 16; pp. 2921 - 2925
Main Author Perkins, Michael V
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 07.04.2008
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
Animals
antitumor agents
enzyme inhibitors
Enzyme Inhibitors - chemical synthesis
macrolides
Macrolides - chemical synthesis
Porifera - chemistry
Spiro Compounds
Stereoisomerism
synthetic methods
total synthesis
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Summary:Problem solved: Spirastrellolide A methyl ester (see picture) is a potent phosphatase 2A inhibitor and has been the subject of considerable synthetic interest since its isolation in 2003. Paterson and co‐workers have now succeeded in the total synthesis of this compound by using a flexible modular strategy. This total synthesis and previous studies towards fragments for spectroscopic comparison and stereochemical determination is summarized.
Bibliography:http://dx.doi.org/10.1002/anie.200800486
istex:78C4DC62DF460707AC4E87A68287DBE37E2332ED
ArticleID:ANIE200800486
ark:/67375/WNG-ZFQ33HQ6-B
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.200800486