The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study

• Published in: Journal of cosmetic dermatology Vol. 24; no. 7; pp. e70324 - n/a
• Main Authors: Su, Zhen, Zheng, Yue, Yi, Jinling, Lai, Wei, Ye, Congxiu
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.07.2025
• Subjects: Administration, Cutaneous; Adult; barrier function; Centella; Ceramides - administration & dosage; Ceramides - adverse effects; cosmetics; Face; facial cream; Female; Humans; Middle Aged; moisturizer; Original; Pantothenic Acid - administration & dosage; Pantothenic Acid - adverse effects; Pantothenic Acid - analogs & derivatives; Plant Extracts - administration & dosage; Plant Extracts - adverse effects; Plant Leaves; Prospective Studies; redness; sensitive skin; Skin - drug effects; Skin Care - methods; Skin Cream - administration & dosage; Skin Cream - adverse effects; skin hydration; Treatment Outcome; Triterpenes - administration & dosage; Triterpenes - adverse effects; Water Loss, Insensible - drug effects; Young Adult; facial cream; moisturizer; sensitive skin; skin hydration; redness; barrier function; cosmetics
• ISSN: 1473-2130; 1473-2165; 1473-2165
• DOI: 10.1111/jocd.70324

ABSTRACT Background Sensitive skin is a hyperreactive condition with rising prevalence. A holistic skin care routine is crucial for management. Selecting appropriate skin care products is of great concern in clinical practice. Aims To assess the effectiveness and safety of a facial cream containing Centella asiatica leaf extract, ceramide NP, and panthenol in Chinese females with sensitive skin. Methods In this single‐center, prospective, self‐controlled study, 88 female participants applied the cream on their whole face, with follow‐ups at Day 2, Weeks 1, 2, and 4. The primary endpoint was the change rate of the SS—10 global score at Week 2. Non‐invasive skin parameters and subject self‐assessment were conducted. Adverse events (AEs) were monitored. Results Mean SS‐10 scores dropped by 66% and 76% after 2 and 4 weeks. Four symptoms (skin irritation, tautness, itching, and redness) were significantly reduced. TEWL decreased at Weeks 1 and 2, and skin pH at Week 1 and Weeks 2 and 4. SCH increased at all time points and sebum secretion at Week 4. EI, a* value, and facial red area rapidly decreased. Greater improvements were seen in the sensitive skin group compared with the slightly sensitive skin group. All AEs were mild and self‐limiting. Conclusions This study showed the facial cream was effective and safe for 4‐week use. It provided immediate relief of facial redness and discomfort, strengthened skin barrier, and modulated pH and sebum secretion, indicating favorable soothing and barrier‐repairing properties for sensitive skin.