Cutaneous Fusarium solani infection in childhood acute lymphoblastic leukaemia

• Published in: Clinical and experimental dermatology Vol. 34; no. 5; pp. e117 - e119
• Main Authors: Cooke, N. S., Feighery, C., Armstrong, D. K. B., Walsh, M., Dempsey, S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2009
• Subjects: Child, Preschool; Dermatomycoses - complications; Dermatomycoses - immunology; Female; Fusarium - isolation & purification; Fusarium solani; Humans; Immunocompromised Host; Opportunistic Infections - complications; Opportunistic Infections - immunology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
• ISSN: 0307-6938; 1365-2230
• DOI: 10.1111/j.1365-2230.2008.03164.x

Summary Cutaneous involvement is often an initial presentation of infection with Fusarium species, which occurs more commonly in immunocompromised hosts and may be either localized or widespread. Skin lesions typically appear as red or grey macules, which may develop central ulceration and black eschar. Secondary dissemination to extracutaneous organs may occur in immunocompromised hosts, especially those with prolonged and severe neutropenia. We describe a case of widespread cutaneous involvement after infection with Fusarium solani in childhood acute lymphoblastic leukaemia that responded successfully to treatment with prolonged liposomal amphotericin B.