Spectroscopic imaging of human brain glutamate by water-suppressed J-refocused coherence transfer at 4.1 T

The authors reported the development and implementation of a water-suppressed J-refocused coherence transfer sequence to observe glutamate in human brain at 4.1 T. The sequence is modeled for I2S2 and I2S2M spin systems analytically and plotted for a range of echo times. In this sequence, water supp...

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Bibliographic Details
Published inMagnetic resonance in medicine Vol. 36; no. 1; p. 7
Main Authors Pan, J W, Mason, G F, Pohost, G M, Hetherington, H P
Format Journal Article
LanguageEnglish
Published United States 01.07.1996
Subjects
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Body Water
Brain - metabolism
Carbon - chemistry
Electron Spin Resonance Spectroscopy
Energy Transfer
Glutamic Acid - chemistry
Glutamic Acid - metabolism
Glutamine - metabolism
Gyrus Cinguli - metabolism
Humans
Magnetic Resonance Spectroscopy
Models, Chemical
Phantoms, Imaging
Signal Processing, Computer-Assisted
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Summary:The authors reported the development and implementation of a water-suppressed J-refocused coherence transfer sequence to observe glutamate in human brain at 4.1 T. The sequence is modeled for I2S2 and I2S2M spin systems analytically and plotted for a range of echo times. In this sequence, water suppression and refocusing of J-coupled resonances are achieved through a brief multiple quantum step without significant loss of signal. Phantom data are shown. Human brain spectroscopic imaging of glutamate, acquired with a total echo of 36 ms, demonstrates the application of the sequence to observe gray and white matter differences in glutamate content.
ISSN:0740-3194
DOI:10.1002/mrm.1910360103