Intravascular hemolytic transfusion reaction without detectable antibodies: A case report and review of literature

A case of intravascular hemolytic transfusion reaction without detectable antibodies occurring in a 55-year-old male is reported. Specificity for the C antigen in the Rh system was demonstrated by technetium-99m red cell survival studies. A cell-mediated mechanism of hemolysis was suspected and inve...

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Bibliographic Details
Published inVox sanguinis Vol. 51; no. 2; p. 96
Main Authors Harrison, C R, Hayes, T C, Trow, L L, Benedetto, A R
Format Journal Article
LanguageEnglish
Published England 01.01.1986
Subjects
Antigens, Surface
Epitopes
Erythrocyte Aggregation - etiology
Erythrocyte Aging
Erythrocyte Transfusion
Erythrocytes - immunology
Hemoglobinuria - blood
Humans
Immunity, Cellular
Isoantibodies - analysis
Lymphocyte Activation
Male
Middle Aged
Rh-Hr Blood-Group System - immunology
Technetium
Transfusion Reaction
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Summary:A case of intravascular hemolytic transfusion reaction without detectable antibodies occurring in a 55-year-old male is reported. Specificity for the C antigen in the Rh system was demonstrated by technetium-99m red cell survival studies. A cell-mediated mechanism of hemolysis was suspected and investigated. Previously reported cases are reviewed and discussed. The entity of intravascular hemolytic transfusion reaction associated with minimal symptoms and no detectable antibodies deserves further investigation.
ISSN:0042-9007
DOI:10.1111/j.1423-0410.1986.tb00222.x