Reaction in leprosy: acute phase reactant response during and after remission

Sera from 25 patients with type 1 (Lepra), upgrading and downgrading, and type 2 (erythema nodosum leprosum [ENL]) reactions were assayed, during the reaction and after its clinical remission, for changes in levels of alpha-1-antitrypsin (A1A) and C-reactive protein (CRP). The results were compared...

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Published inInternational journal of dermatology Vol. 31; no. 9; p. 632
Main Authors Sehgal, V N, Bhattacharya, S N, Shah, Y, Sharma, V K, Gupta, C K
Format Journal Article
LanguageEnglish
Published England 01.09.1992
Subjects
Adolescent
Adult
alpha 1-Antitrypsin - metabolism
C-Reactive Protein - metabolism
Erythema Nodosum - blood
Erythema Nodosum - therapy
Female
Humans
Leprosy, Borderline - blood
Leprosy, Borderline - immunology
Leprosy, Borderline - therapy
Leprosy, Lepromatous - blood
Leprosy, Lepromatous - immunology
Leprosy, Lepromatous - therapy
Male
Middle Aged
Predictive Value of Tests
Reaction Time
Remission Induction
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Summary:Sera from 25 patients with type 1 (Lepra), upgrading and downgrading, and type 2 (erythema nodosum leprosum [ENL]) reactions were assayed, during the reaction and after its clinical remission, for changes in levels of alpha-1-antitrypsin (A1A) and C-reactive protein (CRP). The results were compared with those from normal healthy adults and patients of leprosy without history and/or clinical evidence of reaction. The A1A levels correlated better with changes in status of type 1 reaction; whereas CRP levels correlated well with alterations in type 2 reactions and were definitely superior to A1A in this situation for monitoring the course of these episodes.
ISSN:0011-9059
DOI:10.1111/j.1365-4362.1992.tb03981.x