Increase in Lipid Peroxidation in Rat Gastric Mucosal Lesions Induced by Water-Immersion Restraint Stress
The role of lipid peroxidation in the pathogenesis of gastric ulcer was investigated in a rat model produced by water-immersion restraint stress. After the immersion of rats in 23°C water with restraint, blood flow of the gastric wall was significantly decreased and hemorrhagic erosions were seen in...
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Published in | Journal of Clinical Biochemistry and Nutrition Vol. 1; no. 3; pp. 271 - 277 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Gifu
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
1986
Japan Science and Technology Agency |
Subjects | |
Online Access | Get full text |
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Summary: | The role of lipid peroxidation in the pathogenesis of gastric ulcer was investigated in a rat model produced by water-immersion restraint stress. After the immersion of rats in 23°C water with restraint, blood flow of the gastric wall was significantly decreased and hemorrhagic erosions were seen in the body of the stomach. Thiobarbituric acid-reactive substances, an index of lipid peroxidation, in the gastric mucosa were significantly increased after the stress. These results suggest that lipid peroxidation may play a role in the pathogenesis of gastric mucosal lesions induced by stress. |
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ISSN: | 0912-0009 1880-5086 |
DOI: | 10.3164/jcbn.1.271 |