Increase in Lipid Peroxidation in Rat Gastric Mucosal Lesions Induced by Water-Immersion Restraint Stress

The role of lipid peroxidation in the pathogenesis of gastric ulcer was investigated in a rat model produced by water-immersion restraint stress. After the immersion of rats in 23°C water with restraint, blood flow of the gastric wall was significantly decreased and hemorrhagic erosions were seen in...

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Published inJournal of Clinical Biochemistry and Nutrition Vol. 1; no. 3; pp. 271 - 277
Main Authors YOSHIKAWA, Toshikazu, MIYAGAWA, Haruo, YOSHIDA, Norimasa, SUGINO, Shigeru, KONDO, Motoharu
Format Journal Article
LanguageEnglish
Published Gifu SOCIETY FOR FREE RADICAL RESEARCH JAPAN 1986
Japan Science and Technology Agency
Subjects
gastric mucosal lesions
lipid peroxidation
microcirculation
thiobarbituric acid-reactive substances
water-immersed restraint stress
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Summary:The role of lipid peroxidation in the pathogenesis of gastric ulcer was investigated in a rat model produced by water-immersion restraint stress. After the immersion of rats in 23°C water with restraint, blood flow of the gastric wall was significantly decreased and hemorrhagic erosions were seen in the body of the stomach. Thiobarbituric acid-reactive substances, an index of lipid peroxidation, in the gastric mucosa were significantly increased after the stress. These results suggest that lipid peroxidation may play a role in the pathogenesis of gastric mucosal lesions induced by stress.
ISSN:0912-0009
1880-5086
DOI:10.3164/jcbn.1.271