Advances in Molecular biomarker for early diagnosis of Osteoarthritis

• Published in: Biomolecular concepts Vol. 10; no. 1; pp. 111 - 119
• Main Authors: Munjal, Akul, Bapat, Santul, Hubbard, Daniel, Hunter, Monte, Kolhe, Ravindra, Fulzele, Sadanand
• Format: Journal Article
• Language: English
• Published: Berlin De Gruyter 09.08.2019; Walter de Gruyter GmbH
• Subjects: Aging; Arthritis; Biomarker; Biomarkers; Chondrocytes; Diagnosis; Endocrinology; Gene expression; Joint diseases; miRNA; Oncology; Osteoarthritis; Pain; Synovial fluid; Urine

Osteoarthritis (OA) is a chronic degenerative joint disease. The pathogenesis is poorly understood. What is known is that OA is characterized by imbalance in anabolic and catabolic gene expression in articular chondrocytes. This results in bone on bone articulations resulting in impaired mobility an...