Advances in Molecular biomarker for early diagnosis of Osteoarthritis

Osteoarthritis (OA) is a chronic degenerative joint disease. The pathogenesis is poorly understood. What is known is that OA is characterized by imbalance in anabolic and catabolic gene expression in articular chondrocytes. This results in bone on bone articulations resulting in impaired mobility an...

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Bibliographic Details
Published inBiomolecular concepts Vol. 10; no. 1; pp. 111 - 119
Main Authors Munjal, Akul, Bapat, Santul, Hubbard, Daniel, Hunter, Monte, Kolhe, Ravindra, Fulzele, Sadanand
Format Journal Article
LanguageEnglish
Published Berlin De Gruyter 09.08.2019
Walter de Gruyter GmbH
Subjects
Aging
Arthritis
Biomarker
Biomarkers
Chondrocytes
Diagnosis
Endocrinology
Gene expression
Joint diseases
miRNA
Oncology
Osteoarthritis
Pain
Synovial fluid
Urine
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Summary:Osteoarthritis (OA) is a chronic degenerative joint disease. The pathogenesis is poorly understood. What is known is that OA is characterized by imbalance in anabolic and catabolic gene expression in articular chondrocytes. This results in bone on bone articulations resulting in impaired mobility and joint pain. Although the cause of OA is unknown, comorbidities include: aging, obesity, and mechanical stress. Currently the only diagnostic modalities are radiology and physical examination, and early detection is rare. Biomarkers are quantifiable substances, and their presence can be suggestive of a certain phenomenon or disease. Biomarkers are popular for early diagnosis for pathological conditions in the fields of oncology, cardiology, and endocrinology. This review has systematically reviewed the literature about biomarkers in the field of OA, specifically protein, miRNA, and metabolic biomarkers found in the blood, urine, and synovial fluid.
ISSN:1868-5021
1868-5021
1868-503X
DOI:10.1515/bmc-2019-0014