Superimposed linear psoriasis: differential therapeutic response of linear and nonlinear lesions
Summary Linear psoriasis is a very unusual clinical variation of psoriasis. Typical clinical features include early onset of erythematosquamous lesions along Blaschko’s lines, ability to elicit psoriatic features, absence of pruritus and positive family history for psoriasis. Recently, the term ‘sup...
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Published in | Clinical and experimental dermatology Vol. 34; no. 5; pp. e177 - e179 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.07.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Summary
Linear psoriasis is a very unusual clinical variation of psoriasis. Typical clinical features include early onset of erythematosquamous lesions along Blaschko’s lines, ability to elicit psoriatic features, absence of pruritus and positive family history for psoriasis. Recently, the term ‘superimposed linear psoriasis’ was coined for cases with development of nonlinear psoriatic lesions at predilection sites in later life. We report a 19‐year‐old woman meeting all criteria for the diagnosis of superimposed linear psoriasis including typical histological features. Remarkably, treatment with topical steroids and dithranol cleared the psoriatic lesions on predilection sites whereas the linear lesions were resistant to topical therapy. Linear psoriatic lesions are believed to be caused by genetic alterations in early embryogenesis leading to loss of heterozygosity at a gene locus involved in the pathogenesis of psoriasis. Comparison of mosaic keratinocytes derived from linear lesions with wild‐type keratinocytes from the same person may therefore allow identification of key regulatory genes. |
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Bibliography: | ark:/67375/WNG-CNCF8FF1-9 istex:99FF42B1AC7828F541597967CBA74384EAC417EE ArticleID:CED3021 Conflict of interest: none declared. Parts of this paper were presented as a poster at the 5th Congress of the Baltic Association of Dermatovenereology, 8–10 September 2005, Vilnius, Lithuania. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3 |
ISSN: | 0307-6938 1365-2230 |
DOI: | 10.1111/j.1365-2230.2008.03021.x |