Periodontal repair in dogs: recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration

• Published in: Journal of periodontology (1970) Vol. 66; no. 2; p. 131
• Main Authors: Sigurdsson, T J, Lee, M B, Kubota, K, Turek, T J, Wozney, J M, Wikesjö, U M
• Format: Journal Article
• Language: English
• Published: United States 01.02.1995
• Subjects: Alveolar Bone Loss - drug therapy; Alveolar Bone Loss - surgery; Animals; Ankylosis; Bone Morphogenetic Proteins; Bone Regeneration - drug effects; Dental Cementum - drug effects; Dental Cementum - physiology; Dogs; Drug Evaluation, Preclinical; Growth Substances - pharmacology; Growth Substances - therapeutic use; Humans; Lactic Acid; Male; Polyglycolic Acid; Polymers - pharmacology; Polymers - therapeutic use; Proteins - pharmacology; Proteins - therapeutic use; Random Allocation; Recombinant Proteins - pharmacology; Recombinant Proteins - therapeutic use; Regeneration - drug effects; Root Resorption

This study evaluated bone and cementum regeneration following periodontal reconstructive surgery using recombinant human bone morphogenetic protein-2 (rhBMP-2) in six beagle dogs. Surgically created mandibular supraalveolar premolar tooth defects in contralateral jaw quadrants were randomly assigned...