Effect of anaesthetic agents administered to the mothers on transcutaneous bilirubin levels in the neonates

• Published in: Acta Paediatrica Vol. 99; no. 7; pp. 993 - 996
• Main Authors: Alkan, S, Tıraş, Ü, Dallar, Y, Sunay, D
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2010; Blackwell
• Subjects: Adult; Anesthesia, Conduction; Anesthesia, General; Anesthesia, Obstetrical - adverse effects; Anesthetics - adverse effects; Bilirubin - blood; Biological and medical sciences; Bupivacaine; Bupivacaine - adverse effects; Bupivacaine - analogs & derivatives; Cesarean Section; Female; General aspects; Humans; hyperbilirubinemia; Hyperbilirubinemia, Neonatal - chemically induced; Infant, Newborn; levobupivacaine; Male; Medical sciences; Methyl Ethers - adverse effects; neonate; Pregnancy; sevoflurane; Volatile compound; Human; Pediatrics; Levobupivacaine; neonate; Bilirubin; Percutaneous route; Local anesthetic; Sevoflurane; Bupivacaine; Hyperbilirubinemia; Newborn; General anesthetic; Mother; Carboxamide; Organic amide; Anilide; Halogen Organic compounds
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/j.1651-2227.2010.01761.x

Aim:  To investigate the effect of anaesthetic agents on transcutaneous bilirubin levels during the first 24 h in neonates delivered by caesarean section. Methods:  A total of 168 neonates delivered by caesarean section, during which sevoflurane was used for general anaesthesia (group A), bupivacaine for spinal anaesthesia (group B), levobupivacaine for epidural anaesthesia (group C) and 155 neonates delivered vaginally were included in the study. Transcutaneous bilirubin levels (TBLs) of infants were measured during the first 24 h and compared with each other. Results:  The TBLs in neonates delivered vaginally were higher than those delivered by caesarean section, but the difference was not significant. TBLs were higher in groups A and C than in group B (p = 0.034, p = 0.011 respectively). TBLs were higher in group C than in group A, but the difference was not significant (p > 0.05). When the groups were compared with vaginal delivery group, TBLs in groups A and C were found higher (p = 0.03, p = 0.022 respectively). Conclusion:  The route of delivery had no effect on TBL. While bupivacaine was found to have no effect on neonatal bilirubin levels, levobupivacaine increased neonatal biluribin levels, but further studies are needed for definite results.