Variation in cutaneous sensation between synthetic pyrethroid insecticides

• Published in: Contact dermatitis Vol. 13; no. 3; p. 140
• Main Authors: Flannigan, S A, Tucker, S B
• Format: Journal Article
• Language: English
• Published: England 01.08.1985
• Subjects: Administration, Topical; alpha-Tocopherol - analogs & derivatives; Humans; Insecticides - toxicity; Nitriles; Paresthesia - chemically induced; Permethrin; Phenylacetates - toxicity; Pyrethrins - toxicity; Sensation - drug effects; Tocopherols; Vitamin E - analogs & derivatives; Vitamin E - pharmacology
• ISSN: 0105-1873
• DOI: 10.1111/j.1600-0536.1985.tb02526.x

Synthetic pyrethroids are potent insecticides, utilized for food protection and general pest control. Numerous investigations have indicated that ultra-low volume applications are effective and may eliminate the developing problem of resistance to the currently utilized insecticides. The most prominent health symptom that accompanies topical contact with these agents appears to be a cutaneous sensation, paresthesia. In this investigation, a substantial difference in the degree of paresthesia was noted between the formulated grade of 4 synthetic pyrethroids. Also, dl-alpha tocopheryl acetate was statistically validated as an efficacious therapeutic agent for cutaneous exposure to these insecticides.