MSCs Become Collagen-Type I Producing Cells with Different Phenotype in Allogeneic and Syngeneic Bone Marrow Transplantation

• Published in: International journal of molecular sciences Vol. 22; no. 9; p. 4895
• Main Authors: Rusch, Robert Maximilian, Ogawa, Yoko, Sato, Shinri, Morikawa, Satoru, Inagaki, Emi, Shimizu, Eisuke, Tsubota, Kazuo, Shimmura, Shigeto
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.05.2021; MDPI
• Subjects: Animals; Antigens; Bone marrow; Bone Marrow Transplantation; Collagen; Collagen (type I); Collagen Type I - biosynthesis; Eye diseases; Fibrosis; Genotype & phenotype; graft-versus-host disease (GVHD); Inflammation; Lacrimal Apparatus - cytology; Lacrimal gland; mesenchymal stem cells (MSCs); Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Mesenchyme; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Pathology; Phenotype; Phenotypes; Stem cell transplantation; Stem cells; Stroma; Syngeneic grafts; Therapeutic applications; Tissue engineering; Transgenic animals; Transgenic mice; Transplantation; Transplantation, Homologous; Transplantation, Isogeneic; mesenchymal stem cells (MSCs); lacrimal gland; graft-versus-host disease (GVHD)

Mesenchymal stem cells (MSCs) have been widely used in therapeutic applications for many decades. However, more and more evidence suggests that factors such as the site of origin and pre-implantation treatment have a crucial impact on the result. This study investigates the role of freshly isolated...