Emerging PEGylated drugs

• Published in: Expert opinion on emerging drugs Vol. 14; no. 2; p. 363
• Main Authors: Kang, Jung Seok, Deluca, Patrick P, Lee, Kang Choon
• Format: Journal Article
• Language: English
• Published: England 01.06.2009
• Subjects: Drug Carriers - therapeutic use; Drug Delivery Systems; Drugs, Investigational - therapeutic use; Humans; Immunoglobulin Fragments - chemistry; Peptides - chemistry; Peptides - pharmacokinetics; Peptides - therapeutic use; Polyethylene Glycols - chemistry; Polyethylene Glycols - therapeutic use; Proteins - chemistry; Proteins - pharmacokinetics; Proteins - therapeutic use; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacokinetics; Small Molecule Libraries - therapeutic use

PEGylation is a pharmaceutical technology that involves the covalent attachment of polyethylene glycol (PEG) to a drug to improve its pharmacokinetic, pharmacodynamic, and immunological profiles, and thus, enhance its therapeutic effect. Currently, PEGylation is used to modify proteins, peptides, ol...