Emerging PEGylated drugs

PEGylation is a pharmaceutical technology that involves the covalent attachment of polyethylene glycol (PEG) to a drug to improve its pharmacokinetic, pharmacodynamic, and immunological profiles, and thus, enhance its therapeutic effect. Currently, PEGylation is used to modify proteins, peptides, ol...

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Bibliographic Details
Published inExpert opinion on emerging drugs Vol. 14; no. 2; p. 363
Main Authors Kang, Jung Seok, Deluca, Patrick P, Lee, Kang Choon
Format Journal Article
LanguageEnglish
Published England 01.06.2009
Subjects
Drug Carriers - therapeutic use
Drug Delivery Systems
Drugs, Investigational - therapeutic use
Humans
Immunoglobulin Fragments - chemistry
Peptides - chemistry
Peptides - pharmacokinetics
Peptides - therapeutic use
Polyethylene Glycols - chemistry
Polyethylene Glycols - therapeutic use
Proteins - chemistry
Proteins - pharmacokinetics
Proteins - therapeutic use
Small Molecule Libraries - chemistry
Small Molecule Libraries - pharmacokinetics
Small Molecule Libraries - therapeutic use
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Summary:PEGylation is a pharmaceutical technology that involves the covalent attachment of polyethylene glycol (PEG) to a drug to improve its pharmacokinetic, pharmacodynamic, and immunological profiles, and thus, enhance its therapeutic effect. Currently, PEGylation is used to modify proteins, peptides, oligonucleotides, antibody fragments, and small organic molecules. Research groups are striving to improve the consistencies of PEGylated drugs and to PEGylate commercialized proteins and small organic molecules. Furthermore, the PEGylations of novel medications, like oligonucleotides and antibody fragments, are being pursued to improve their bioavailabilities. This active research in the PEGylation field and the continued growth of the biopharmaceutical market predicts that PEGylated drugs have a bright future.
ISSN:1744-7623
DOI:10.1517/14728210902907847