Emerging PEGylated drugs
PEGylation is a pharmaceutical technology that involves the covalent attachment of polyethylene glycol (PEG) to a drug to improve its pharmacokinetic, pharmacodynamic, and immunological profiles, and thus, enhance its therapeutic effect. Currently, PEGylation is used to modify proteins, peptides, ol...
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| Published in | Expert opinion on emerging drugs Vol. 14; no. 2; p. 363 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.06.2009
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| Subjects | |
| Online Access | Get more information |
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| Abstract | PEGylation is a pharmaceutical technology that involves the covalent attachment of polyethylene glycol (PEG) to a drug to improve its pharmacokinetic, pharmacodynamic, and immunological profiles, and thus, enhance its therapeutic effect. Currently, PEGylation is used to modify proteins, peptides, oligonucleotides, antibody fragments, and small organic molecules. Research groups are striving to improve the consistencies of PEGylated drugs and to PEGylate commercialized proteins and small organic molecules. Furthermore, the PEGylations of novel medications, like oligonucleotides and antibody fragments, are being pursued to improve their bioavailabilities. This active research in the PEGylation field and the continued growth of the biopharmaceutical market predicts that PEGylated drugs have a bright future. |
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| AbstractList | PEGylation is a pharmaceutical technology that involves the covalent attachment of polyethylene glycol (PEG) to a drug to improve its pharmacokinetic, pharmacodynamic, and immunological profiles, and thus, enhance its therapeutic effect. Currently, PEGylation is used to modify proteins, peptides, oligonucleotides, antibody fragments, and small organic molecules. Research groups are striving to improve the consistencies of PEGylated drugs and to PEGylate commercialized proteins and small organic molecules. Furthermore, the PEGylations of novel medications, like oligonucleotides and antibody fragments, are being pursued to improve their bioavailabilities. This active research in the PEGylation field and the continued growth of the biopharmaceutical market predicts that PEGylated drugs have a bright future. |
| Author | Deluca, Patrick P Lee, Kang Choon Kang, Jung Seok |
| Author_xml | – sequence: 1 givenname: Jung Seok surname: Kang fullname: Kang, Jung Seok organization: SungKyunKwan University, College of Pharmacy, Drug Targeting Laboratory, Suwon 440-746, Korea – sequence: 2 givenname: Patrick P surname: Deluca fullname: Deluca, Patrick P – sequence: 3 givenname: Kang Choon surname: Lee fullname: Lee, Kang Choon |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19453284$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Drug Carriers - therapeutic use Drug Delivery Systems Drugs, Investigational - therapeutic use Humans Immunoglobulin Fragments - chemistry Peptides - chemistry Peptides - pharmacokinetics Peptides - therapeutic use Polyethylene Glycols - chemistry Polyethylene Glycols - therapeutic use Proteins - chemistry Proteins - pharmacokinetics Proteins - therapeutic use Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacokinetics Small Molecule Libraries - therapeutic use |
| Title | Emerging PEGylated drugs |
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