Integrating Metabolomics and Gut Microbiota to Identify Key Biomarkers and Regulatory Pathways Underlying Metabolic Heterogeneity in Childhood Obesity

• Published in: Nutrients Vol. 17; no. 11; p. 1876
• Main Authors: Xia, Zhiwei, Li, Yan, Yin, Jiyong, Gong, Zhaolong, Sun, Jing, Shen, Shi, Yang, Yi, Liu, Tingting, Wang, Liyuan, Huo, Junsheng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.05.2025; MDPI
• Subjects: Amino acids; Antibiotics; Biological markers; Biomarkers; Biomarkers - metabolism; Blood lipids; Blood pressure; Body mass index; Child; Child, Preschool; Childhood; Children; Children & youth; China; Constipation; Diabetes; Diarrhea; Diet; Female; Gastrointestinal Microbiome - physiology; Glucose; Gut microbiota; Health aspects; Health care; Humans; Lipids; Male; Membrane lipids; Metabolism; Metabolites; Metabolomics - methods; Microbiota; Microbiota (Symbiotic organisms); Nervous system; Nutrition research; Obesity; Obesity in children; Pediatric Obesity - metabolism; Pediatric Obesity - microbiology; Pediatrics; Probiotics; Questionnaires; RNA; RNA, Ribosomal, 16S - genetics; Type 2 diabetes; China; California; United States; Massachusetts; multi-omics; metabolic heterogeneity; metabolomics; gut microbiota; childhood obesity

Background/Objectives: Individuals with childhood obesity exhibit significant metabolic heterogeneity, necessitating precise biomarkers for risk stratification and assessment. This multi-omics investigation characterizes metabolic and microbial signatures underlying divergent metabolic phenotypes in...