Case report: First manifestation of multiple sclerosis temporally correlated with COVID-19 vaccination

There are several case reports describing a temporal correlation between the first clinical manifestation of multiple sclerosis (MS) and the occurrence of relapses with vaccination against SARS-CoV-2. Here we report a case of a 33-year-old male who developed partial right upper and lower extremities...

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Published inFrontiers in neurology Vol. 14; p. 1097799
Main Authors Czarnowska, Agata, Kapica-Topczewska, Katarzyna, Tarasów, Eugeniusz, Tarasiuk, Joanna, Chorąży, Monika, Kochanowicz, Jan, Kułakowska, Alina
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.02.2023
Subjects
autoimmune condition
case report
COVID-19
multiple sclerosis
Neurology
SARS-CoV-2
vaccination
COVID-19
case report
SARS-CoV-2
multiple sclerosis
autoimmune condition
vaccination
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Summary:There are several case reports describing a temporal correlation between the first clinical manifestation of multiple sclerosis (MS) and the occurrence of relapses with vaccination against SARS-CoV-2. Here we report a case of a 33-year-old male who developed partial right upper and lower extremities numbness 2 weeks after receiving Johnson & Johnson's Janssen COVID-19 vaccine. The brain MRI performed during diagnostics in the Department of Neurology detected several demyelinating lesions, one with enhancement. Oligoclonal bands were present in the cerebrospinal fluid. The patient was treated with high-dose glucocorticoid therapy with improvement and the diagnosis of MS was made. It seems plausible that the vaccination revealed the underlying autoimmune condition. Cases like the one we reported here are rare, and-based on current knowledge-the benefits of vaccination against SARS-CoV-2 far outweigh the potential risks.
Bibliography:Reviewed by: Karlo Toljan, Cleveland Clinic, United States; Vincenzo Brescia Morra, University of Naples Federico II, Italy
Edited by: Noel G. Carlson, The University of Utah, United States
This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Neurology
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2023.1097799