OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease

• Published in: World journal of gastroenterology : WJG Vol. 14; no. 31; pp. 4923 - 4927
• Main Authors: Li, Mei, Gao, Xiang, Guo, Chang-Cun, Wu, Kai-Chun, Zhang, Xin, Hu, Pin-Jin
• Format: Journal Article
• Language: English
• Published: United States Department of Gastroenterology,the First Affiliated Hospital of Zhongshan University,Guangzhou 510089,Guangdong Province,China%Department of Gastroenterology,Xijing Hospital of the Fourth Military Medical University,Xi'an 710032,Shaanxi Province,China 21.08.2008; The WJG Press and Baishideng
• Subjects: Adult; Asian Continental Ancestry Group - genetics; Case-Control Studies; China - epidemiology; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Inflammatory Bowel Diseases - ethnology; Inflammatory Bowel Diseases - genetics; Male; Middle Aged; Nod2 Signaling Adaptor Protein - genetics; Organic Cation Transport Proteins - genetics; Polymorphism, Single Nucleotide; Prospective Studies; Rapid Communication; Solute Carrier Family 22 Member 5; 治疗方法; 病理机制; 肠溃疡; Inflammatory bowel disease; Carnitine/organic cation transporter gene; Crohn's disease; CARD15; Ulcerative colitis
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.14.4923

AIM： To investigate the single nucleotide polymorphism （SNPs） distribution of NOD2/CARD15 （R702W, G908R）, OCTN1 1672CFT and OCTN2-207G/C in Chinese patients with inflammatory bowel disease （IBD）. METHODS： A total of 61 patients with Crohn＇s disease （CD）, 151 patients with ulcerative colitis （UC）, and 200 unrelated healthy controls were genotyped. Genotyping was performed by sequence specific primer polymerase chain reaction （PCR-SSP） or by restriction fragment length polymorphism （PCR-RFLP） analysis. RESULTS： Among the subjects in our study groups, including patients with CD, UC and healthy controls, none had OCTN and CARD15 variants and very rare IBD family history was found in our patients with the percentage of 0 （0/61 with CD） and 1.3% （2/151 with UC）. CONCLUSION： Our results indicate that although OCTN or CARD15 variation is associated with susceptibility to IBD in Western populations, these might be rare and may not be associated with susceptibility to IBD in Chinese patients.