Sketching neoteric solvents for boosting drugs bioavailability

• Published in: Journal of controlled release Vol. 311-312; pp. 225 - 232
• Main Authors: Álvarez, María S., Zhang, Yanfei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2019
• Subjects: bioavailability; catalytic activity; DES; drug formulations; drugs; Eco-friendly solvent; environmental impact; Green chemistry; industry; ionic liquids; NADES; Pharmaceutical application; raw materials; solubility; THEDES; therapeutics; Green chemistry; DES; Eco-friendly solvent; Pharmaceutical application; NADES; THEDES
• ISSN: 0168-3659; 1873-4995; 1873-4995
• DOI: 10.1016/j.jconrel.2019.09.008

Emerging neoteric solvents are being the subject of growing attention due to their lower cost and environmental impact, so they are being applied in a broad spectrum of industries. Among them, the pharmaceutical sector is demanding new environmentally friendly and non-toxic solvents able to enhance drugs solubility and stability. The introduction of ionic liquids turned out to be a breakthrough in the field of Green Chemistry opening up new separation and catalysis opportunities. In this sense, the options represented by Deep Eutectic Solvents make up an attractive alternative due to the low cost of their raw material, simple synthesis, and eco-friendly character. In line with these findings, Therapeutic Deep Eutectic Solvents and Natural Deep Eutectic Solvents are new and promising alternatives to improve the bioavailability of drugs in pharmaceutical formulations. This leading article is focused on providing a general picture of the advantages and drawbacks of these new solvents as well as the main research lines and perspectives to achieve efficient drugs delivery systems. [Display omitted]