Effects of environmental enrichment on anxiety responses, spatial memory and cytochrome c oxidase activity in adult rats

• Published in: Brain research bulletin Vol. 98; pp. 1 - 9
• Main Authors: Sampedro-Piquero, P, Zancada-Menendez, C, Begega, A, Rubio, S, Arias, J.L
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2013
• Subjects: Analysis of Variance; Animals; Anxiety - enzymology; Anxiety - pathology; Anxiety - physiopathology; Cytochrome c oxidase activity; Disease Models, Animal; Electron Transport Complex IV - metabolism; Elevated zero-maze; Environment; Environmental enrichment; Male; Maze Learning - physiology; Memory - physiology; Neurology; Prefrontal Cortex - metabolism; Radial-arm water maze; Rats; Rats, Wistar; Space Perception - physiology; Statistics as Topic; Time Factors; Wistar rat; EPM; Cg; prelimbic cortex; dorsal dentate gyrus; control group; COx; Radial-arm water maze; SPL; spatial learning group; Wistar rat; BlA; central amygdala; environmental enrichment group; basolateral amygdala; EE; MO; IL; paraventricular hypothalamic nucleus; ventral dentate gyrus; dorsal hippocampal cornu ammonis; dCA1 dCA3; BNST; elevated zero-maze; HPA; EZM; environmental enrichment + spatial learning group; EE+SPL; ventral hippocampal cornu ammonis; long-term potentiation; vCA1 vCA3; multivariate analysis of variance; medial orbital cortex; infralimbic cortex; PVNh; four-arm radial water maze; LTP; PVNt; paraventricular thalamic nucleus; hypothalamic–pituitary–adrenal axis; OD; glucocorticoids; GC; MANOVA; bed nucleus stria terminalis; elevated plus-maze; Acb; 4-RAWM; time by entries; dDG; cingulate cortex; Cytochrome c oxidase activity; CO; environmental enrichment; cytochrome c oxidase histochemistry; TbE; vDG; ANOVA of repeated measures; accumbens nucleus; RM ANOVA; PL; optical density; CeA; Elevated zero-maze; Environmental enrichment; environmental enrichment+spatial learning group
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/j.brainresbull.2013.06.006

Highlights • EE reduced the anxiety-like behaviours in the elevated zero-maze. • EE group had a better performance in the 4-RAWM in the first sessions. • EE reduced the COx activity in brain regions related to anxiety in the spatial task. • Hippocampus had a different pattern of COx activity along its septo-temporal axis.