Real-life evaluation of a human immunodeficiency virus screening algorithm using a single combined p24 antigen–antibody assay

• Published in: European journal of clinical microbiology & infectious diseases Vol. 32; no. 3; pp. 425 - 430
• Main Authors: Fanmi, A. N., Ramière, C., Tardy, J. C., André, P.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.03.2013; Springer; Springer Nature B.V
• Subjects: Algorithms; Antibodies; Antigens; Architects; Automation; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Clinical Laboratory Techniques - methods; Diagnostic Errors - statistics & numerical data; Enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - methods; Enzymes; France; HIV; HIV Antibodies - blood; HIV Core Protein p24 - blood; HIV Infections - diagnosis; Human immunodeficiency virus; Human immunodeficiency virus 1; Human viral diseases; Humans; Immune system; Immunoassay; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infection; Infections; Infectious diseases; Internal Medicine; Laboratories; Male; Mass Screening - methods; Medical Microbiology; Medical sciences; Polymerase chain reaction; Real-Time Polymerase Chain Reaction; RNA; RNA, Viral - blood; Sensitivity and Specificity; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virology; Virology - methods; France; Germany; Human Immunodeficiency Virus Screening; Human Immunodeficiency Virus Infection; Grey Zone; Human Immunodeficiency Virus; Gp36 Antibody; Immunopathology; Microbiology; Retroviridae; AIDS; Medical screening; Enzyme immunoassay; Immune deficiency; Lentivirus; Algorithm; Infection; Virus; Viral disease; Human immunodeficiency virus

Since May 2010, human immunodeficiency virus (HIV) screening in France has been performed using a single combined fourth-generation assay. One of our major concerns is to verify that this screening strategy is able to diagnose HIV primary infection as soon as possible. Thus, the sensitivity and spec...