Formulation of diclofenac for dermal delivery

[Display omitted] Diclofenac (DF) was first synthesized in the 1960’s and is currently available as ophthalmic, oral, parenteral, rectal and skin preparations. This review focuses on the administration of DF to the skin. As a member of the non-steroidal anti-inflammatory (NSAID) group of drugs the p...

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Published inInternational journal of pharmaceutics Vol. 473; no. 1-2; pp. 607 - 616
Main Authors Goh, Choon Fu, Lane, Majella E.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.2014
Subjects
Administration, Cutaneous
Animals
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Chemistry, Pharmaceutical
Delivery
Diclofenac
Diclofenac - chemistry
Diclofenac - pharmacokinetics
Formulation
Humans
NSAID
Salts
Skin
Skin Absorption
Salts
Skin
Delivery
NSAID
Formulation
Diclofenac
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Summary:[Display omitted] Diclofenac (DF) was first synthesized in the 1960’s and is currently available as ophthalmic, oral, parenteral, rectal and skin preparations. This review focuses on the administration of DF to the skin. As a member of the non-steroidal anti-inflammatory (NSAID) group of drugs the primary indications of DF are for the management of inflammation and pain but it is also used to treat actinic keratosis. The specific aims of this paper are to: (i) provide an overview of the pharmacokinetics and metabolism of DF following oral and topical administration; (ii) examine critically the various formulation approaches which have been investigated to enhance dermal delivery of DF; and (iii) identify new formulation strategies for enhanced DF skin penetration.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2014.07.052