PC Gene Affects Milk Production Traits in Dairy Cattle

• Published in: Genes Vol. 15; no. 6; p. 708
• Main Authors: Du, Aixia, Guo, Zijiao, Chen, Ao, Xu, Lingna, Sun, Dongxiao, Han, Bo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.05.2024; MDPI
• Subjects: Alleles; Animal lactation; Animal models; Animals; Association analysis; Cattle; Cattle - genetics; Cow's milk; Dairy cattle; Fatty acids; Female; GATA-1 protein; GATA1 Transcription Factor - genetics; Genes; genomic selection; Lactation; Lactation - genetics; Livestock industry; Metabolism; Milk; Milk - metabolism; Milk production; milk production trait; Milk proteins; Mutation; Nutrition; PC gene; Plasmids; Polymorphism, Single Nucleotide; Population genetics; Population studies; Production data; Proteins; Single-nucleotide polymorphism; transcription factor; China; Beijing China; United States > US; PC gene; milk production trait; genomic selection; transcription factor; single-nucleotide polymorphism
• ISSN: 2073-4425; 2073-4425
• DOI: 10.3390/genes15060708

In previous work, we found that was differentially expressed in cows at different lactation stages. Thus, we deemed that may be a candidate gene affecting milk production traits in dairy cattle. In this study, we found the polymorphisms of by resequencing and verified their genetic associations with milk production traits by using an animal model in a cattle population. In total, we detected six single-nucleotide polymorphisms (SNPs) in . The single marker association analysis showed that all SNPs were significantly associated with the five milk production traits ( < 0.05). Additionally, we predicted that allele G of 29:g.44965658 in the 5' regulatory region created binding sites for TF GATA1 and verified that this allele inhibited the transcriptional activity of by the dual-luciferase reporter assay. In conclusion, we proved that had a prominent genetic effect on milk production traits, and six SNPs with prominent genetic effects could be used as markers for genomic selection (GS) in dairy cattle, which is beneficial for accelerating the improvement in milk yield and quality in Chinese Holstein cows.