Opposing effects of acute and chronic d -amphetamine on decision-making in rats

Highlights • Acute amphetamine administration decreases loss sensitivity in reward-based decision-making. • Amphetamine sensitization increases loss sensitivity in reward-based decision-making. • Chronic amphetamine increases dendritic spine density in the dorsolateral striatum.

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Bibliographic Details
Published inNeuroscience Vol. 345; pp. 218 - 228
Main Authors Wong, Scott A, Thapa, Raj, Badenhorst, Cecilia A, Briggs, Alicia R, Sawada, Justan A, Gruber, Aaron J
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 14.03.2017
Subjects
addiction
Amphetamine - administration & dosage
Animals
Catheters, Indwelling
Central Nervous System Stimulants - administration & dosage
Corpus Striatum - cytology
Corpus Striatum - drug effects
Decision Making - drug effects
Decision Making - physiology
decision-making
Dendritic Spines - drug effects
dopamine
Impulsive Behavior - drug effects
Impulsive Behavior - physiology
learning
Male
Neurology
Psychotropic Drugs - administration & dosage
Random Allocation
Rats, Long-Evans
Reward
striatum
Time Factors
PBS
reward prediction error
dorsomedial striatum
RPE
ventral striatum
addiction
amphetamine
DLS
PFA
learning
DMS
MSNs
dorsolateral striatum
striatum
decision-making
Phosphate-Buffered Saline
AMPH
paraformaldehyde
Medium Spiny Neurons
VS
dopamine
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Summary:Highlights • Acute amphetamine administration decreases loss sensitivity in reward-based decision-making. • Amphetamine sensitization increases loss sensitivity in reward-based decision-making. • Chronic amphetamine increases dendritic spine density in the dorsolateral striatum.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.04.021