Diffusion Tensor Imaging and Chemical Shift Imaging Assessment of Heterogeneity in Low Grade Glioma Under Temozolomide Chemotherapy

• Published in: Cancer investigation Vol. 25; no. 8; pp. 706 - 710
• Main Authors: Sijens, P. E., Heesters, M. A.A.M., Enting, R. H., van der Graaf, W. T.A., Potze, J. H., Irwan, R., Meiners, L. C., Oudkerk, M.
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.12.2007; Taylor & Francis
• Subjects: Antineoplastic Agents, Alkylating - therapeutic use; Brain Neoplasms - drug therapy; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Brain tumor; Choline - metabolism; Dacarbazine - analogs & derivatives; Dacarbazine - therapeutic use; Diffusion Magnetic Resonance Imaging; Diffusion tensor imaging; Glioma; Glioma - drug therapy; Glioma - metabolism; Glioma - pathology; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged
• ISSN: 0735-7907; 1532-4192
• DOI: 10.1080/07357900701564028

Diffusion tensor imaging and multiple voxel magnetic resonance spectroscopy were performed in the MRI follow-up of a patient with a glioma treated with temozolomide chemotherapy. Tumor shrinkage was paralleled by reductions in choline level and by increases in apparent diffusion coefficient indicating decreased cellularity. Within the tumor, choline level and apparent diffusion coefficient showed a significant inverse correlation (P < 0.01). Fractional anisotropy distribution in the tumor correlated positively with N-acetyl aspartate level (P < 0.001), indicating that these parameters reflect (remaining) axonal structure. Tumor lactate level, also found to decrease under therapy, did not correlate with any other parameter.