Risk factors for alcohol-related liver injury in the island population of China：A population-based case-control study

• Published in: World journal of gastroenterology : WJG Vol. 14; no. 14; pp. 2255 - 2261
• Main Authors: Shen, Zhe, Li, You-Ming, Yu, Chao-Hui, Shen, Yi, Xu, Lei, Xu, Cheng-Fu, Chen, Jin-Jin, Ye, Hua, Xu, Gen-Yun
• Format: Journal Article
• Language: English
• Published: United States Department of Gastroenterology, The First Affiliated Hospital, Medicine School, Zhejiang University,Hangzhou 310003, Zhejiang Province, China%Department of Statistics, Medicine School, Zhejiang University, Hangzhou 310000, Zhejiang Province, China%Department of Clinical Laboratory, The First Affiliated Hospital, Medicine School, Zhejiang University,Hangzhou 310003, Zhejiang Province, China 14.04.2008; The WJG Press and Baishideng
• Subjects: Adult; Aged; Alcohol Drinking - adverse effects; Alcoholic Beverages; Case-Control Studies; China; Cluster Analysis; Female; Humans; Liver - diagnostic imaging; Liver - injuries; Liver Diseases - epidemiology; Male; Middle Aged; Obesity - complications; Rapid Communication; Risk Factors; Ultrasonography; 治疗方法; 流行病学; 肝损伤; Alcohol; Prevalence; Case-controlstudv; Eoidemiology; Liver injury
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.14.2255

AIM：To investigate the association of alcohol dose, duration of drinking and obesity with abnormal alcohol-related liver injury indicators, the prevalence of alcohol-related liver injury in the island population of China.METHODS：Randomized multistage stratified cluster sampling from the island population of China was used in the population-based case-control study. Then interview, physical examination, laboratory assessments and ultrasonography were done. RESULTS：Daily alcohol intake ≥ 20 g, duration of drinking ≥ 5 years and obesity were closely related to alcohol-related liver injury （P 〈 0.05）. The odds-ratio （OR） （95% CI） was 1.965 （1.122-3.442）, 3.412 （1.789-6.507） and 1.887 （1.261-2.824）, respectively. The prevalence rate of alcohol-related liver injury in ≥ 20 g daily alcohol intake group and 〈 20 g daily alcohol intake group was 37.14% and 12.06%, respectively. The prevalence rate of alcohol-related liver injury in ≥ 5 years drinking group and 〈 5 years drinking group was 34.44% and 8.53%, respectively. No significant dose-response relation was found between daily alcohol intake and abnormal alcohol-related liver injury indicators as well as between duration of drinking and abnormal alcohol-related liver injury indicators. There was no significant difference in the prevalence of alcohol-related liver injury between beer drinking group and yellow rice wine drinking group, hard liquor drinking group, multiple drinking group.CONCLUSION：The risk threshold of daily alcohol intake is 20 g and duration of drinking inducing alcohol-related liver injury 5 years in the island population of China. Liver injury induced by obesity should be concerned.