Regulation of Water-Soluble Phenolic Acid Biosynthesis in Salvia miltiorrhiza Bunge

• Published in: Applied biochemistry and biotechnology Vol. 170; no. 6; pp. 1253 - 1262
• Main Authors: Ma, Pengda, Liu, Jingling, Zhang, Chenlu, Liang, Zongsuo
• Format: Journal Article
• Language: English
• Published: New York Springer New York 01.07.2013; Springer; Springer Nature B.V
• Subjects: Biochemistry; Biological and medical sciences; Biomedical research; Biosynthesis; Biotechnology; Chemistry; Chemistry and Materials Science; Environmental regulations; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Plant - physiology; Genetic Enhancement - methods; Herbal medicine; Hydrogen peroxide; Hydroxybenzoates - chemistry; Hydroxybenzoates - metabolism; Lamiaceae; Natural products; Pharmaceuticals; Phenols; Pigmentation; Plants, Genetically Modified - metabolism; Salvia miltiorrhiza; Salvia miltiorrhiza - physiology; Solubility; Ultraviolet radiation; Water - chemistry; Yeasts; China; Molecular level; Rosmarinic acid; Cell level; Lithospermic acid B; Phenolic acid; Biosynthesis; Water soluble compound; Regulation(control); Salvia miltiorrhiza; Labiatae; Dicotyledones; Angiospermae; Spermatophyta
• ISSN: 0273-2289; 1559-0291
• DOI: 10.1007/s12010-013-0265-4

Salvia miltiorrhiza Bunge (Lamiaceae) root, generally called Danshen, is an important herb in Chinese medicine widely used for treatment of various diseases. Phenolic acids in S. miltiorrhiza , as important effective compounds, have become a new research focus in plant secondary metabolism in recent years. This review summarizes the recent advances in the regulation of water-soluble phenolic acid biosynthesis in S. miltiorrhiza via regulators at molecular level, such as the phenylalanine ammonia-lyase gene ( PAL ), cinnamic acid 4-hydroxylase gene ( C4H ), 4-coumarate-CoA ligase gene ( 4CL ), tyrosine aminotransferase gene ( TAT ), 4-hydroxyphenylpyruvate reductase gene ( HPPR ), 4-hydroxyphenylpyruvated dioxygenase gene ( HPPD ), hydroxycinnamoyl-CoA:hydroxyphenyllactate hydroxycinnamoyl transferase-like gene ( RAS -like), and v-myb avian myeloblastosis viral oncogene homolog 4 gene ( MYB4 ), and production of anthocyanin pigmentation 1 gene ( AtPAP1 ), and via regulators at cell level, such as methyl jasmonate, salicylic acid, abscisic acid, polyamines, metal ions, hydrogen peroxide (H 2 O 2 ), ultraviolet-B radiation, and yeast elicitor.