Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1–40) fibrillogenesis

Abstract The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1–40) peptide was investigated. Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ1–40 peptides und...

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Bibliographic Details
Published inBiomaterials Vol. 33; no. 18; pp. 4443 - 4450
Main Authors Chan, Ho-Man, Xiao, Lehui, Yeung, Kai-Ming, Ho, See-Lok, Zhao, Dan, Chan, Wing-Hong, Li, Hung-Wing
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.06.2012
Subjects
Advanced Basic Science
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - ultrastructure
Dentistry
Metal Nanoparticles - chemistry
Metal Nanoparticles - ultrastructure
Microscopy, Electron, Transmission
Nanoparticle
Peptide
Peptide Fragments - chemistry
Peptide Fragments - ultrastructure
Quantum Dots
Self-assembly
Surface modification
Surface modification
Self-assembly
Nanoparticle
Peptide
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Summary:Abstract The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1–40) peptide was investigated. Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ1–40 peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis. It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ1–40 fibrillogenesis.
Bibliography:ObjectType-Article-1
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ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2012.03.024