Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population

AKT1 (V-akt murine thymoma viral oncogene homolog 1) is a protein kinase isoform of AKT. Five single-nucleotide polymorphisms, rs3803300, rs1130214, rs3730358, rs2498799 and rs2494732, at the genomic region of AKT1 have been reported to be significantly associated with schizophrenia. We tested for t...

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Published inPsychiatric genetics Vol. 16; no. 1; p. 39
Main Authors Liu, Yu-Li, Fann, Cathy Shen-Jang, Liu, Chih-Min, Wu, Jer-Yuarn, Hung, Shuen-Iu, Chan, Hung-Yu, Chen, Jiahn-Jyh, Pan, Chia-Ching, Liu, Shih-Kai, Hsieh, Ming H, Hwang, Tzung-Jeng, Ouyang, Wen-Chen, Chen, Chun-Ying, Lin, Jin-Jia, Chou, Frank Huang-Chih, Chueh, Ching-Mo, Liu, Wei-Ming, Tsuang, Ming-Ming, Faraone, Stephen V, Tsuang, Ming T, Chen, Wei J, Hwu, Hai-Gwo
Format Journal Article
LanguageEnglish
Published England 01.02.2006
Subjects
Genetic Markers
Haplotypes
Humans
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-akt - genetics
Schizophrenia - genetics
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Taiwan
Taiwan
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Summary:AKT1 (V-akt murine thymoma viral oncogene homolog 1) is a protein kinase isoform of AKT. Five single-nucleotide polymorphisms, rs3803300, rs1130214, rs3730358, rs2498799 and rs2494732, at the genomic region of AKT1 have been reported to be significantly associated with schizophrenia. We tested for the presence of these five single-nucleotide polymorphisms in a Taiwanese population by genotyping 218 co-affected schizophrenia families. Both single locus and haplotypes analyses showed no association of these single-nucleotide polymorphisms with schizophrenia. These findings fail to support AKT1 as a susceptibility gene for schizophrenia in the Taiwanese population.
ISSN:0955-8829
DOI:10.1097/01.ypg.0000180681.80546.f3