Recent trends in hepatitis B virus infection in the general Korean population

• Published in: The Korean journal of internal medicine Vol. 28; no. 4; pp. 413 - 419
• Main Authors: Kim, Hyuck, Shin, A Ri, Chung, Hoe Hoon, Kim, Min Kyoung, Lee, Ji Sung, Shim, Jae-Jun, Kim, Byung-Ho
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Association of Internal Medicine 01.07.2013; 대한내과학회
• Subjects: Adolescent; Adult; Age Distribution; Age Factors; Aged; Biomarkers - blood; Chi-Square Distribution; Child; Cross-Sectional Studies; Female; Health Surveys; Hepatitis B - diagnosis; Hepatitis B - epidemiology; Hepatitis B - prevention & control; Hepatitis B Surface Antigens - blood; Hepatitis B Vaccines - therapeutic use; Humans; Longitudinal Studies; Male; Middle Aged; Original; Prevalence; Republic of Korea - epidemiology; Seroepidemiologic Studies; Socioeconomic Factors; Time Factors; Young Adult; 내과학; Republic of Korea; Hepatitis B surface antigens; Prevalence; Hepatitis B virus; Age groups; Korea
• ISSN: 1226-3303; 2005-6648
• DOI: 10.3904/kjim.2013.28.4.413

Hepatitis B virus (HBV) is the major cause of chronic liver disease in Korea, but viral prevalence has decreased because of hepatitis B vaccination programs. In this study, we investigated longitudinal changes in HBV in fection in the general Korean population. HBV surface antigen (hepatitis B surface antigen, HBsAg) seropositivity was assessed from the Korea National Health and Nutrition Examination Survey (I to V). In total, 50,140 subjects were tested for serum HBsAg positivity over a period of 12 years (1998 to 2010). The prevalence of HBsAg seropositivity decreased over the study period. The rates of HBsAg carriers were 4.61% in 1998, 4.60% in 2001, 3.69% in 2005, 3.01% in 2008, and 2.98% in 2010 (p < 0.0001). The reduction in HBV infection rates was more prominent in younger age groups. Among teenagers (10 to 19 years), the percentage of HBsAg carriers decreased from 2.2% in 1998 to 0.12% in 2010 (p < 0.0001). Among those aged 10 to 39 years, the percentage of HBV infection decreased from 4.72% in 1998 to 2.29% in 2010 (p < 0.0001). However, no decreasing trend in HBsAg positivity was observed among those aged 50 or older (p > 0.05). Neither gender nor socioeconomic status were associated with the decreased prevalence of HBsAg carriers. HBV infection has decreased in the Korean population since the advent of vaccination programs. However, the decrease is limited to the younger population, and viral persistence remains in the middle-aged and older population.