Study on the kinetics of bradykinin level in the wound produced by thermal injury in the ear burn model in mice

The kinetics of bradykinin derived from localized thermal injury on vascular-permeability were investigated in mice with experimental ear burn. The leakage of plasma into the ear tissue by accelerated vascular-permeability reached the maximum at 3 hr and decreased gradually until 6 hr after the ther...

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Bibliographic Details
Published inNihon yakurigaku zasshi Vol. 99; no. 6; p. 445
Main Authors Imokawa, H, Ando, K, Kubota, T, Isono, E, Inoue, H, Ishida, H
Format Journal Article
LanguageJapanese
Published Japan 1992
Subjects
Animals
Bradykinin - metabolism
Bradykinin - physiology
Burns - metabolism
Capillary Permeability
Disease Models, Animal
Ear, External - injuries
Mice
Pain
Protease Inhibitors - pharmacology
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Summary:The kinetics of bradykinin derived from localized thermal injury on vascular-permeability were investigated in mice with experimental ear burn. The leakage of plasma into the ear tissue by accelerated vascular-permeability reached the maximum at 3 hr and decreased gradually until 6 hr after the thermal injury. The contents of bradykinin increased by the thermal injury and the increment continued up to 24 hr. Although the bradykinin contents in the burned ear decreased by using a protease inhibitor, the hyperpermeability of injured ear vessels was unchanged by protease inhibitors. These results suggest that bradykinin is concerned with the pain reaction rather than vascular-permeability.
ISSN:0015-5691
DOI:10.1254/fpj.99.445