Advancing the Frontiers of Neuroelectrodes: A Paradigm Shift towards Enhanced Biocompatibility and Electrochemical Performance

• Published in: Polymers Vol. 16; no. 11; p. 1457
• Main Authors: Wang, Qin, Liu, Yiyang, Zhang, Baolin, Dong, Jianghui, Wang, Liping
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.05.2024; MDPI
• Subjects: Analysis; Biocompatibility; Blood; Carbon; Chemical synthesis; Chromium alloys; Diffraction; Dimyristoyl phosphatidylcholine; Dimyristoylphosphatidylcholine; Electrochemical analysis; Electrodes; Electrons; Identification and classification; Infrared analysis; Infrared spectroscopy; Iron oxides; Metal oxides; Methods; Nanomaterials; Nanoparticles; neural recordings; Neurological diseases; Nickel chromium alloys; Phosphatidylcholine; Photoelectrons; Polyethylene glycol; Polyethyleneimine; Polymers; Properties; Signal to noise ratio; Spectrum analysis; Structure; superparamagnetic iron oxide nanoparticles; Ultrasonic imaging; X ray photoelectron spectroscopy; X-ray spectroscopy; X-rays; Zeta potential; China; United States > US; Dimyristoyl phosphatidylcholine; neural recordings; superparamagnetic iron oxide nanoparticles
• ISSN: 2073-4360; 2073-4360
• DOI: 10.3390/polym16111457

The aim of this study is the fabrication of unprecedented neuroelectrodes, replete with exceptional biological and electrical attributes. Commencing with the synthesis of polyethylene glycol and polyethyleneimine-modified iron oxide nanoparticles, the grafting of Dimyristoyl phosphatidylcholine was embarked upon to generate DMPC-SPION nanoparticles. Subsequently, the deposition of DMPC-SPIONs onto a nickel-chromium alloy electrode facilitated the inception of an innovative neuroelectrode-DMPC-SPION. A meticulous characterization of DMPC-SPIONs ensued, encompassing zeta potential, infrared spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction analyses. Evaluations pertaining to hemolysis and cytotoxicity were conducted to ascertain the biocompatibility and biosafety of DMPC-SPIONs. Ultimately, a comprehensive assessment of the biocompatibility, electrochemical properties, and electrophysiological signal acquisition capabilities of DMPC-SPION neuroelectrodes was undertaken. These findings conclusively affirm the exemplary biocompatibility, electrochemical capabilities, and outstanding capability in recording electrical signals of DMPC-SPION neuroelectrodes, with an astounding 91.4% augmentation in electrode charge and a noteworthy 13% decline in impedance, with peak potentials reaching as high as 171 μV and an impressive signal-to-noise ratio of 15.92. Intriguingly, the novel DMPC-SPION neuroelectrodes herald an innovative pathway towards injury repair as well as the diagnosis and treatment of neurological disorders.