Emerging platforms for co-utilization of one-carbon substrates by photosynthetic organisms

• Published in: Current opinion in biotechnology Vol. 53; no. C; pp. 201 - 208
• Main Authors: Singh, Abhay K, Kishore, Ganesh M, Pakrasi, Himadri B
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2018; Elsevier
• Subjects: Biocatalysis; Carbon - metabolism; Carbon Cycle; Photosynthesis; Phototrophic Processes; Ribulose-Bisphosphate Carboxylase - metabolism
• ISSN: 0958-1669; 1879-0429
• DOI: 10.1016/j.copbio.2018.02.002

[Display omitted] •One-carbon substrates are promising sustainable feedstocks for bioprocesses.•New tools are enabling catalytic and energetic improvements of the native pathways.•Synthetic pathways can provide new avenues for efficient carbon assimilation.•Photomixotrophic production systems enable unparalleled energy and carbon yield. One-carbon substrates have generated increasing attention as long-term sustainable feedstocks for biobased production of fuels and chemicals. However, their physicochemical properties present significant biological and operational challenges for commercial bioprocesses including kinetically slower substrate activation, high energetic cost of assimilation, low mass transfer, substrate toxicity, and low productivity titers. Several different routes including optimization of native pathways, synthetic pathways, and hybrid methods are being explored to overcome these challenges. Integration of emerging biological solutions with process improvements is enabling faster bioprocess development for cost-effective conversion of one-carbon substrates into fuels and chemicals.