Prismatic Silver Nanoparticles Decorated on Graphene Oxide Sheets for Superior Antibacterial Activity

Spherical silver nanoparticles (Ag NPs) and silver nanoprisms (Ag NPrsms) were synthesized and decorated on graphene oxide (GO) nanosheets. The Ag contents were 29% and 23% in the GO−Ag NPs and GO−Ag NPrsms, respectively. The Ag NPrsms exhibited stronger (111) crystal signal than Ag NPs. The GO−Ag N...

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Published inPharmaceutics Vol. 14; no. 5; p. 924
Main Authors Truong, Thi Tuong Vi, Chen, Chien-Chang, Kumar, Selvaraj Rajesh, Hu, Chih-Chien, Chen, Dave W, Liu, Yu-Kuo, Lue, Shingjiang Jessie
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 24.04.2022
MDPI
Subjects
antibacterial activity
Bacteria
Crystal structure
E coli
Fourier transforms
Graphene
graphene oxide
Morphology
Nanomaterials
Nanoparticles
nanoprisms
Potassium
Silver
silver nanoparticles
Transmission electron microscopy
United States > US
Japan
Taiwan
antibacterial activity
graphene oxide
nanoparticles
silver nanoparticles
nanoprisms
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Summary:Spherical silver nanoparticles (Ag NPs) and silver nanoprisms (Ag NPrsms) were synthesized and decorated on graphene oxide (GO) nanosheets. The Ag contents were 29% and 23% in the GO−Ag NPs and GO−Ag NPrsms, respectively. The Ag NPrsms exhibited stronger (111) crystal signal than Ag NPs. The GO−Ag NPrsms exhibited higher Ag (I) content (75.6%) than GO-Ag NPs (69.9%). Increasing the nanomaterial concentration from 25 to 100 µg mL−1 improved the bactericidal efficiency, and the antibacterial potency was in the order: GO−Ag NPrsms > GO−Ag NPs > Ag NPrsms > Ag NPs > GO. Gram-positive Staphylococcus aureus (S. aureus) was more vulnerable than Gram-negative Escherichia coli (E. coli) upon exposure to these nanomaterials. The GO−Ag NPrsms demonstrated a complete (100%) bactericidal effect against S. aureus at a concentration of 100 µg mL−1. The GO−Ag composites outperformed those of Ag or GO due to the synergistic effect of bacteriostatic Ag particles and GO affinity toward bacteria. The levels of reactive oxygen species produced in the bacteria−nanomaterial mixtures were highly correlated to the antibacterial efficacy values. The GO−Ag NPrsms are promising as bactericidal agents to suppress biofilm formation and inhibit bacterial infection.
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These authors contributed equally to this work.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14050924