A nitric oxide-releasing prodrug promotes apoptosis in human renal carcinoma cells: Involvement of reactive oxygen species

JS-K is a nitric oxide (NO)-releasing prodrug of the O2-arylated diazeniumdiolate group that shows pronounced cytotoxicity and antitumor properties in numerous cancer models, including in vitro as well as in vivo. Reactive oxygen species (ROS) induce carcinogenesis by altering the redox status, caus...

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Published inOpen Chemistry Vol. 19; no. 1; pp. 635 - 645
Main Authors Xie, Jindong, Chen, Lieqian, Huang, Dongqiang, Yue, Weiwei, Chen, Jingyu, Liu, Chunxiao
Format Journal Article
LanguageEnglish
Published De Gruyter 26.05.2021
Subjects
apoptosis
JS-K
nitric oxide
renal carcinoma cells
ROS
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Summary:JS-K is a nitric oxide (NO)-releasing prodrug of the O2-arylated diazeniumdiolate group that shows pronounced cytotoxicity and antitumor properties in numerous cancer models, including in vitro as well as in vivo. Reactive oxygen species (ROS) induce carcinogenesis by altering the redox status, causing increment in vulnerability to oxidative stress.
ISSN:2391-5420
2391-5420
DOI:10.1515/chem-2020-0075