Do heterotrimeric G proteins redistribute upon G protein-coupled receptor stimulation in platelets?

• Published in: Platelets (Edinburgh) Vol. 17; no. 6; pp. 397 - 404
• Main Authors: Kahner, Bryan N., Quinton, Todd M., Langan, Sarah, Kunapuli, Satya P.
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.09.2006; Taylor & Francis
• Subjects: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology; Adenosine Diphosphate; Animals; Blood Platelets - metabolism; Calcium; G protein-coupled receptor; GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism; GTP-Binding Protein Regulators - physiology; GTP-Binding Proteins - metabolism; Humans; knockout mice; Mice; Mice, Knockout; Peptide Fragments; protease activating receptor; Receptors, Opioid - drug effects; Receptors, Proteinase-Activated - drug effects; Receptors, Proteinase-Activated - genetics; Receptors, Proteinase-Activated - physiology; Receptors, Purinergic P2 - genetics; Receptors, Purinergic P2 - physiology; Receptors, Purinergic P2Y1; Vasoconstrictor Agents - pharmacology

Previous studies have proposed that stimulation of G protein-coupled receptors can cause a redistribution of G proteins to other receptors. The redistribution would cause a greater functional sensitivity of unsensitized 'secondary' receptors toward their agonists. Using platelets as a mode...