A case of severe coronary spasm associated with 5-fluorouracil chemotherapy

• Published in: The Korean journal of internal medicine Vol. 27; no. 3; pp. 342 - 345
• Main Authors: Kim, Sang-Min, Kwak, Cheol-Hoon, Lee, Bora, Kim, Seong Beom, Sir, Jung-Ju, Cho, Wook-Hyun, Choi, Suk-Koo
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Association of Internal Medicine 01.09.2012; 대한내과학회
• Subjects: Aged, 80 and over; Angina Pectoris - chemically induced; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Calcium Channel Blockers - administration & dosage; Case Report; Colonic Neoplasms - drug therapy; Coronary Angiography; Coronary Vasospasm - chemically induced; Coronary Vasospasm - diagnosis; Coronary Vasospasm - therapy; Drug-Eluting Stents; Electrocardiography; Fluorouracil - administration & dosage; Fluorouracil - adverse effects; Humans; Leucovorin - administration & dosage; Leucovorin - adverse effects; Male; Nifedipine - administration & dosage; Nitroglycerin - administration & dosage; Organoplatinum Compounds - administration & dosage; Organoplatinum Compounds - adverse effects; Percutaneous Coronary Intervention - instrumentation; Recurrence; Severity of Illness Index; Treatment Outcome; Vasodilator Agents - administration & dosage; 내과학; Coronary vasospasm; Angina pectoris; Calcium channel blockers; Fluorouracil
• ISSN: 1226-3303; 2005-6648
• DOI: 10.3904/kjim.2012.27.3.342

Cardiotoxicity associated with 5-fluorouracil (FU) is an uncommon, but potentially lethal, condition. The case of an 83-year-old man with colon cancer who developed chest pain during 5-FU infusion is presented. The electrocardiogram (ECG) showed pronounced ST elevation in the lateral leads, and the chest pain was resolved after infusion of nitroglycerin. A coronary angiogram (CAG) revealed that the patient had significant atherosclerosis in the proximal left circumflex artery. Coronary artery spasm with fixed stenosis was considered, and a drug-eluting stent was implanted. After 8 hours, the patient complained of recurring chest pain, paralleled by ST elevation on the ECG. The chest pain subsided after administration of intravenous nitroglycerin followed by sublingual nifedipine. Repeated CAG showed patency of the previous stent. This case supports the vasospastic hypothesis of 5-FU cardiac toxicity, indicating that a calcium channel blocker may be effective in the prevention or treatment of 5-FU cardiotoxicity.