Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1

• Published in: Neuroscience Vol. 323; pp. 207 - 221
• Main Authors: Freitas-Andrade, M, Naus, C.C
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 26.05.2016
• Subjects: Animals; astrocytes; Astrocytes - metabolism; Connexin 43 - genetics; Connexin 43 - metabolism; connexin43; Humans; Nerve Degeneration - metabolism; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; neurodegeneration; Neurodegenerative Diseases - metabolism; Neurology; Neuroprotection - physiology; pannexin1; BBB; N-methyl- d-aspartate; neurodegeneration; conditioned media; bilateral carotid artery occlusion; FGF1; NVU; carbenoxolone; Aβ; ischemic post-conditioning; blood–brain barrier; fibroblast growth factor; gap junctions; AD; Alzheimer’s disease; connexin43; HSP; pannexins; amyloid-β; connexins; Panxs; middle cerebral artery; BCAO; ODDD; permanent middle cerebral artery occlusion; astrocytes; glial fibrillary acidic protein; oculodentodigital dysplasia; neurofibrillary tangles; heat shock protein; Cbx; NMDA; MFQ; neurovascular unit; intercellular signaling Ca 2+ waves; pannexin1; CM; MCA; ECM; GFAP; GJs; NFTs; Cx43; PD; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; pMCAO; MPTP; ICW; IPC; mefloquine; extracellular matrix; Parkinson’s disease; Cxs
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.04.035

Highlights • Cx43 and Panx1 effects on astrocyte and its implications in neurodegeneration. • Astrocytic Cx43 coupling dissipates toxicity surrounding degenerative neurons. • Hemichannels play a significant role in neuronal viability in degenerative diseases. • Targeting astrocyte survival via Cx43 and Panx1 lowers impact of neurodegeneration.