Dietary fat composition and cardiac events in patients with type 2 diabetes

• Published in: Atherosclerosis Vol. 236; no. 1; pp. 31 - 38
• Main Authors: dos Santos, Ana Luiza Teixeira, Weiss, Tanara, Duarte, Camila Kümmel, Gross, Jorge Luiz, de Azevedo, Mirela Jobim, Zelmanovitz, Themis
• Format: Journal Article
• Language: English
• Published: Ireland 01.09.2014
• Subjects: Aged; alpha-Linolenic Acid; Angina Pectoris - epidemiology; Angina Pectoris - etiology; Anthropometry; Brazil - epidemiology; Cardiovascular; Comorbidity; Death, Sudden; Diabetes Mellitus, Type 2 - epidemiology; Diabetic Cardiomyopathies - epidemiology; Diet Records; Dietary Fats - analysis; Fatty Acids, Unsaturated; Female; Follow-Up Studies; Glycated Hemoglobin A - analysis; Heart Diseases - epidemiology; Heart Diseases - prevention & control; Heart Failure - epidemiology; Humans; Hypolipidemic Agents - therapeutic use; Kidney Function Tests; Male; Middle Aged; Myocardial Infarction - epidemiology; Myocardial Revascularization - utilization; Plant Oils; Proportional Hazards Models; Prospective Studies; Retrospective Studies; Smoking - epidemiology; Type 2 diabetes; Cardiac events; Dietary fatty acids
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2014.06.014

Abstract Objective To evaluate associations of dietary fat composition with the development of cardiac events in patients with type 2 diabetes, without ischemic heart disease who were followed for at least 12 months. Methods In this prospective cohort study the usual diet of patients was retrospectively assessed by a 3-day weighed diet record (WDR). Compliance with the WDR technique was assessed by comparing protein intake estimated from 3-day WDR and 24-h urinary nitrogen output. The following were considered cardiac events: myocardial infarction, myocardial revascularization procedures, congestive heart failure, new-onset angina pectoris, and sudden death. Results A total of 227 patients with type 2 diabetes (aged 59 ± 10 years; 46.0% male), were followed during 4.6 years. In a multivariate Cox regression analysis, the intake of polyunsaturated fatty acids had a protective effect for cardiac events (HR = 0.31, 95% CI: 0.11–0.89; P  = 0.03) adjusted for age, gender, duration of diabetes, smoking, compliance with WDR, using hypolipidemic agents, and the presence of hypertension and diabetic nephropathy. When the fat intake was divided into quartiles, the highest intake of α-linolenic acid (>1.25% of energy) was negatively associated with cardiac events (HR = 0.58, 95% CI: 0.39–0.85; P  = 0.006), adjusted for the same covariates.. Conclusion In patients with type 2 diabetes without ischemic heart disease, a high intake of polyunsaturated fatty acids, especially alpha linolenic acid, was protective for the development of cardiac events..