A Narrative Review Discussing Vasectomy-Related Impact upon the Status of Oxidative Stress and Inflammation Biomarkers and Semen Microbiota

• Published in: Journal of clinical medicine Vol. 12; no. 7; p. 2671
• Main Authors: Doroftei, Bogdan, Ilie, Ovidiu-Dumitru, Maftei, Radu, Scripcariu, Ioana-Sadyie, Armeanu, Theodora, Stoian, Irina-Liviana, Ilea, Ciprian
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.04.2023; MDPI
• Subjects: Antioxidants; Biological markers; Clinical medicine; Complications and side effects; Composition; Development and progression; Diagnosis; DNA methylation; Health aspects; Infertility; Inflammation; Medical research; Medicine, Experimental; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Motility; Oxidative stress; Reproductive health; Review; Risk factors; Semen; Sperm; Vasectomy; Romania; vasectomy; inflammation; semen microbiota; rats; humans; mice; oxidative stress
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12072671

Male contraceptive approaches besides tubal sterilization involve vasectomy and represent the method of choice among midlife men in developing countries thanks to many advantages. However, the subsidiary consequences of this intervention are insufficiently explored since the involved mechanisms may offer insight into a much more complex picture. Thus, in this manuscript, we aimed to reunite all available data by searching three separate academic database(s) (PubMed, Web of Knowledge, and Scopus) published in the past two decades by covering the interval 2000-2023 and using a predefined set of keywords and strings involving "oxidative stress" (OS), "inflammation", and "semen microbiota" in combination with "humans", "rats", and "mice". By following all evidence that fits in the pre-, post-, and vasectomy reversal (VR) stages, we identified a total of n = 210 studies from which only n = 21 were finally included following two procedures of eligibility evaluation. The topic surrounding this intricate landscape has created debate since the current evidence is contradictory, limited, or does not exist. Starting from this consideration, we argue that further research is mandatory to decipher how a vasectomy might disturb homeostasis.