Effect of Thyroid Hormones on Neurons and Neurodevelopment

This review focuses on the current knowledge of the effects of thyroid hormones on central nervous system differentiation and development in animals and the human fetal brain. The outcomes of children with congenital hypothyroidism and of newborns with hypothyroid pregnant mothers are emphasized, fo...

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Bibliographic Details
Published inHormone research in paediatrics Vol. 90; no. 2; p. 73
Main Authors Prezioso, Giovanni, Giannini, Cosimo, Chiarelli, Francesco
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.2018
Subjects
Animals
Brain - drug effects
Brain - embryology
Brain - growth & development
Congenital Hypothyroidism - embryology
Congenital Hypothyroidism - etiology
Female
Humans
Infant, Newborn
Maternal-Fetal Exchange - physiology
Neurons - drug effects
Neurons - physiology
Pregnancy
Thyroid Gland - physiology
Thyroid Hormones - pharmacology
Thyroid Hormones - physiology
Neurodevelopment
Fetal brain
Thyroid hormones
Iodine insufficiency
Congenital hypothyroidism
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Summary:This review focuses on the current knowledge of the effects of thyroid hormones on central nervous system differentiation and development in animals and the human fetal brain. The outcomes of children with congenital hypothyroidism and of newborns with hypothyroid pregnant mothers are emphasized, focusing on how therapies could affect and especially improve the outcomes.
ISSN:1663-2826
DOI:10.1159/000492129