Inhibition of long-term potentiation in the schaffer-CA1 pathway by repetitive high-intensity sound stimulation

• Published in: Neuroscience Vol. 310; pp. 114 - 127
• Main Authors: Cunha, A.O.S, de Oliveira, J.A.C, Almeida, S.S, Garcia-Cairasco, N, Leão, R.M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 03.12.2015
• Subjects: Acoustic Stimulation - adverse effects; Animals; audiogenic seizure; CA1 Region, Hippocampal - physiology; Disease Models, Animal; Electric Stimulation; Electrophysiology; epilepsy; Excitatory Postsynaptic Potentials - physiology; In Vitro Techniques; kindling; Kindling, Neurologic - genetics; Kindling, Neurologic - pathology; Long-Term Potentiation - genetics; Long-Term Potentiation - physiology; LTP; Male; Maze Learning - physiology; Memory - physiology; Neural Inhibition - physiology; Neural Pathways - physiology; Neurology; Psychoacoustics; Rats; Rats, Wistar; Seizures - pathology; Seizures - physiopathology; synapse; synaptic plasticity; HISS; epilepsy; Morris water maze; post-tetanic potentiation; LTP; WAR; PTP; Wistar Audiogenic Rat; genetically epileptic-prone rats; High-intensity sound stimulation; fEPSP; analysis of variance; HFS; ANOVA; GEPRs; audiogenic seizure; MWM; field excitatory post-synaptic potential; long-term depression; synapse; High-frequency stimulation; synaptic plasticity; LTD; long-term potentiation; kindling
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.09.040

Highlights • Hippocampal LTP is inhibited by high-intensity sound stimulation. • In rats prone to audiogenic limbic seizures LTP was not affected by this protocol. • Spatial memory was unaffected in both strains. • LTP is modulated by strong sensory stimulation. • This effect is potentially important for seizure prevention.